Reaktion #57109

ord-7abd0ab0a7dd4cb6b8005d889ed5b4fe

Reaktionsgleichung

COC1(c2cccc(Cl)c2OCc2ccccc2)CCN(CCC2(O)CCCCC2)CC1.Cl
1-[4-(benzyloxy-3-chlorophenyl]-2-(4-methoxypiperidin-1-yl)ethyl]cyclohexanol hydrochloride
COC1CCN(C(=O)C(c2ccc(OCc3ccccc3)c(Cl)c2)C2(O)CCCCC2)CC1
1-[1-[4-(benzyloxy)-3-chlorophenyl]-2-(4-methoxypiperidin-1-yl)-2-oxoethyl]cyclohexanol
→
COC1CCN(CC(c2ccc(OCc3ccccc3)c(Cl)c2)C2(O)CCCCC2)CC1.Cl
1-[1-[4-(benzyloxy)-3-chlorophenyl]-2-(4-methoxypiperidin-1-yl)ethyl]cyclohexanol Hydrochloride

Edukte

COC1(c2cccc(Cl)c2OCc2ccccc2)CCN(CCC2(O)CCCCC2)CC1.Cl
1-[4-(benzyloxy-3-chlorophenyl]-2-(4-methoxypiperidin-1-yl)ethyl]cyclohexanol hydrochloride
COC1CCN(C(=O)C(c2ccc(OCc3ccccc3)c(Cl)c2)C2(O)CCCCC2)CC1
1-[1-[4-(benzyloxy)-3-chlorophenyl]-2-(4-methoxypiperidin-1-yl)-2-oxoethyl]cyclohexanol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In an analogous manner to Example 1, step 2, 1-[1-[4-(benzyloxy-3-chlorophenyl]-2-(4-methoxypiperidin-1-yl)ethyl]cyclohexanol hydrochloride was prepared from 1-[1-[4-(benzyloxy)-3-chlorophenyl]-2-(4-methoxypiperidin-1-yl)-2-oxoethyl]cyclohexanol HRMS: calcd for C27H36ClNO3+H, 458.24620; found (ESI, [M+H]+), 458.2443.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07419980B2uspto-grants-2008_09