Reaktion #570581

Reaktionsgleichung

2-(7-methoxynaphth-1-yl)ethylamine hydrochloride

potassium carbonate

4-imidazoleacetyl chloride hydrochloride

→

N-[2-(7-Methoxynaphth-1-Yl)Ethyl]-4-Imidazolylacetamide

Lösungsmittel

chloroform water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture is cooled
2. 2
   Sonstigethe chloroform phase is evaporated to dryness
3. 3
   SonstigeThe residue is then recrystallized

Vorschrift

0.01 mol of 2-(7-methoxynaphth-1-yl)ethylamine hydrochloride is dissolved in 60 ml of a chloroform/water mixture, and 0.025 mol of potassium carbonate is added under magnetic agitation. The mixture is cooled, and 0.012 mol of 4-imidazoleacetyl chloride hydrochloride is added dropwise. The agitation is maintained for 30 minutes at room temperature and the chloroform phase is evaporated to dryness. The residue is then recrystallized.

Quelle