Reaktion #570578

Reaktionsgleichung

2-(7-methoxynaphth-1-yl)ethylamine hydrochloride

Potassium carbonate

4-chlorobutyryl chloride

→

N-[2-(7-Methoxynaphth-1-Yl)Ethyl]-4-Chlorobutyramide

Lösungsmittel

water chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Trocknenthen the chloroform phase is dried
2. 2
   Sonstigethe residue is recrystallized in a toluene/cyclohexane mixture (1:1)

Vorschrift

0.02 mol of 2-(7-methoxynaphth-1-yl)ethylamine hydrochloride is dissolved in a water/chloroform mixture. Potassium carbonate is added and the mixture is agitated for 15 minutes in an ice bath. 0.022 mol of 4-chlorobutyryl chloride is then added dropwise. The agitation is maintained for half an hour at room temperature; then the chloroform phase is dried, and the residue is recrystallized in a toluene/cyclohexane mixture (1:1).

Quelle