Reaktion #570452

Reaktionsgleichung

p-toluene-sulfonic acid

N-(p-tolyl)urea

α-methylstyrene

acetonitrile

→

N-(α,α,-dimethylbenzyl)-N'-(p-tolyl)urea

phenylisopropylurea

Lösungsmittel

hexane

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling to ambient temperature
2. 2
   Sonstigethe precipitated solid collected
3. 3
   Waschenwashed with hexane
4. 4
   Sonstigerecrystallized from methylene chloride

Vorschrift

A phenylisopropylurea derivative was prepared in accordance with the method of Example 1, as follows: 1.5 parts of N-(p-tolyl)urea was suspended in 3.93 parts of acetonitrile at 55°, and 0.3 parts of p-toluene-sulfonic acid was added. After 1 minute, 4.7 parts of α-methylstyrene were added. The reactants were stirred at 55° C. for 18 hours. After cooling to ambient temperature, 60 parts of hexane was added and the precipitated solid collected, washed with hexane and recrystallized from methylene chloride to afford 2.2 parts of N-(α,α,-dimethylbenzyl)-N'-(p-tolyl)urea.

Quelle