Reaktion #57042

Reaktionsgleichung

Et2O Hexane

daidzein

ammonium formate

CH2Cl2 EtOAc

→

crude product

Ausbeute 84.4%

Dihydrodaidzein

Ausbeute 84.4%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter the reaction complete, the Pd/C was filtered
2. 2
   Einengenthe filtrate was concentrated

Vorschrift

To a solution of daidzein (0.657 g, 2.58 mmol) in methanol (60 mL) was added 10% Pd/C (0.657 g) carefully, following by ammonium formate (0.652 g, 10.3 mmol). The mixture was heated up to 50-60° C. and stirred for one hour. The reaction was monitored by TLC (CH2Cl2/EtOAc=7:2 or 70% Et2O/Hexane) and GC. After the reaction complete, the Pd/C was filtered and the filtrate was concentrated, which gave a crude product (0.558 g) of dihydrodaidzein as the major product and the trans/cis isomers of tetrahydrodaidzein as the minor products. The dihydrodaidzein was purified by standard procedures.

Quelle