Reaktion #570291

Reaktionsgleichung

tetrahydrofurane

triethylamine

thioglycolic methylamide

→

5-cyanomethyl-4-methyl-3-oxothiomorpholine

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONis added
2. 2
   Temperaturcooling
3. 3
   Extraktionextracted with ethyl acetate
4. 4
   WaschenThe extract is washed with water
5. 5
   Sonstigedried
6. 6
   Einengenconcentrated

Vorschrift

To a solution of omega-cyano-allyl bromide (9.07 g) in tetrahydrofurane (60 ml) cooled at -65° C. is added a mixture of triethylamine (9.5 ml) and thioglycolic methylamide (6.13 ml). After 15 minutes, cooling is stopped and the mixture is warmed to 0° C. The mixture is diluted with water and extracted with ethyl acetate. The extract is washed with water, dried, and concentrated to give 5-cyanomethyl-4-methyl-3-oxothiomorpholine (6.86 g).

Quelle