Reaktion #570232

Reaktionsgleichung

1-methyl-3-(3,4-dichlorophenyl)hydantoin

sodium borohydride

→

white crystals

Ausbeute 88.0%

1-methyl-3-(3,4-dichlorophenyl)-4-hydroxyimidazolidine-2-one

Ausbeute 88.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONAfter the addition
2. 2
   workup.STIRRINGthe mixture was stirred for 30 minutes
3. 3
   Temperaturwarmed to room temperature
4. 4
   SonstigeAfter completion of the reaction
5. 5
   Einengenthe reaction mixture was concentrated
6. 6
   workup.ADDITIONwater was added to the residue to deposit crystals
7. 7
   FiltrationThe crystals were filtered
8. 8
   Sonstigerecrystallized from ethanol

Vorschrift

A 10.4 g (0.04 mole) quantity of 1-methyl-3-(3,4-dichlorophenyl)hydantoin was suspended in 80 ml of methanol. The suspension was cooled to 10° C. and 1.5 g of sodium borohydride was added thereto with stirring. After the addition, the mixture was stirred for 30 minutes and warmed to room temperature, followed by further agitation for 2 hours. After completion of the reaction, the reaction mixture was concentrated and water was added to the residue to deposit crystals. The crystals were filtered and recrystallized from ethanol, affording 9.2 g of white crystals in 88% yield.

Quelle