Reaktion #56985

ord-3e3e85cb1abb48dcb6de7856e758b210

Reaktionsgleichung

NC1CCCc2c1[nH]c1ccc(Cl)cc21
6-chloro-2,3,4,9-tetrahydro-1H-carbazol-1-amine
O=C(Cl)c1ccccn1
picolinoyl chloride
O=C(NC1CCCc2c1[nH]c1ccc(Cl)cc21)c1ccccn1
N-(6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl)-2-pyridinecarboxamide

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

N-(6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl)-2-pyridinecarboxamide was prepared from 6-chloro-2,3,4,9-tetrahydro-1H-carbazol-1-amine and picolinoyl chloride in a similar manner as described in Example 14 to give an off-white solid (62% yield). 1H-NMR (DMSO-d6): δ 10.93 (s, 1H), 8.78 (d, 1H), 8.61 (m, 1H), 8.12 (m, 1H), 8.02 (m, 1H), 7.61 (m, 1H), 7.43 (m, 1H), 7.26 (d, 1H), 7.01 (dd, 1H), 5.34 (m, 1H), 2.64 (m, 2H), 2.00 (m, 3H), 1.82 (m, 1H); MS m/z 348 (M+Na).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07419997B2uspto-grants-2008_09