Reaktion #569811

Reaktionsgleichung

N-(4-trifluoromethylphenyl)-3-(4-propoxyphenyl)-4-(N-propylamino)-4,5,-dihydro-1H-pyrazole-1-carboxamide

pyridine

formic acetic anhydride

→

desired compound

Ausbeute 78.3%

N-(4-trifluoromethylphenyl)-3-(4-propoxyphenyl)-4-(N-formyl-N-propylamino)-4,5,-dihydro-1H-pyrazole-1-carboxamide

Ausbeute 78.3%

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenthe reaction mixture was washed with water and brine
2. 2
   Einengenconcentrated in vacuo
3. 3
   Sonstigechromatographed over silica gel

Vorschrift

To 3.0 g (6.7 mmole) of N-(4-trifluoromethylphenyl)-3-(4-propoxyphenyl)-4-(N-propylamino)-4,5,-dihydro-1H-pyrazole-1-carboxamide (Example 586) dissolved in 25 ml of ethyl acetate and cooled to 0° C., was added 2.4 g (30 mmole) of pyridine and 4.0 g (28 mmole) of formic acetic anhydride mixture (Example 621a). After 30 minutes, the reaction mixture was washed with water and brine, concentrated in vacuo, and chromatographed over silica gel using hexanes and ethyl acetate to yield 2.5 g of the desired compound, mp 161°-163° C.

Quelle