Reaktion #569780

ord-ebf7c5b208e54388bf7100d937045ac0

Reaktionsgleichung

CC1(N=C=O)CN(C(=O)Nc2ccc(C(F)(F)F)cc2)N=C1c1ccc(Cl)cc1
N-(4-trifluoromethylphenyl)-3-(4-chlorophenyl)-4-isocyanato-4-methyl-4,5-dihydro-1H-pyrazole-1-carboxamide
CO
methanol
→
COC(=O)NC1(C)CN(C(=O)Nc2ccc(C(F)(F)F)cc2)N=C1c1ccc(Cl)cc1
N-(4-trifluoromethylphenyl)-3-(4-chlorophenyl)-4-carbomethoxyamino-4-methyl-4,5-dihydro-1H-pyrazole-1-carboxamide

Edukte

CC1(N=C=O)CN(C(=O)Nc2ccc(C(F)(F)F)cc2)N=C1c1ccc(Cl)cc1
N-(4-trifluoromethylphenyl)-3-(4-chlorophenyl)-4-isocyanato-4-methyl-4,5-dihydro-1H-pyrazole-1-carboxamide
CO
methanol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Einengenconcentrated in vacuo
  2. 2
    Sonstigerecrystallized from ethyl acetate/hexanes yielding 19.8 g (92%) of a white solid, mp 179°-181° C.

Vorschrift

A solution of 20 g (47 mmole) of N-(4-trifluoromethylphenyl)-3-(4-chlorophenyl)-4-isocyanato-4-methyl-4,5-dihydro-1H-pyrazole-1-carboxamide (Example 1d) in 200 ml of methanol was refluxed for 2 hours, concentrated in vacuo and recrystallized from ethyl acetate/hexanes yielding 19.8 g (92%) of a white solid, mp 179°-181° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05798311uspto-grants-1998_08