Reaktion #569698

Reaktionsgleichung

methyl 4-nitrophenoxyacetate

hydrogen

→

title compound

Ausbeute 97.6%

Methyl 4-aminophenoxyacetate

Ausbeute 97.6%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAt the end of this time, the reaction mixture was filtered
2. 2
   Einengenthe filtrate was concentrated by evaporation under reduced pressure

Vorschrift

A solution of 30.8 g of methyl 4-nitrophenoxyacetate [prepared as described in step (a) above] in 500 ml of methanol was shaken in an atmosphere of hydrogen and in the presence of 5.0 g of 10 w/w palladium-on-charcoal for 6 hours. At the end of this time, the reaction mixture was filtered and the filtrate was concentrated by evaporation under reduced pressure, to give 25.8 g of the title compound having an Rf value=0.79 (on thin layer chromatography on silica gel; developing solvent: ethyl acetate).

Quelle