Reaktion #569560

ord-f17dd989498c491281d5152dc0ae99eb

Reaktionsgleichung

Nc1ncnc2c1ncn2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O1
dATP
O=c1[nH]c2ccccc2c(=O)o1
isatoic anhydride
Nc1ccccc1C(=O)[O-].Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O
anthranilate ATP
→
Nc1ccccc1C(=O)[O-].Nc1ncnc2c1ncn2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O1
Anthranilate dATP
Ausbeute 80.0%

Edukte

Nc1ncnc2c1ncn2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O1
dATP
O=c1[nH]c2ccccc2c(=O)o1
isatoic anhydride
Nc1ccccc1C(=O)[O-].Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O
anthranilate ATP

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigewas purified by chromatography on Lichroprep RP18 (25-40 μm)

Vorschrift

Anthranilate dATP was prepared from dATP and isatoic anhydride by a procedure similar to that described by Hiratsuka {T. Hiratsuka (1982) J. Biol. Chem 257, pp. 13354-13358} for the synthesis of the anthranilate ATP and was purified by chromatography on Lichroprep RP18 (25-40 μm) using 1 mM triethylammonium acetate as eluent.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05798210uspto-grants-1998_08