Reaktion #569239

Reaktionsgleichung

2-(2-fluorophenyl)-2-[(1R)-1-(3,4,5,6-tetrahydro-2H-pyran-2-yl)oxyethyl]oxirane

diisopropyl ether

triphenyl phosphine

3,5-dinitrobenzoic acid

diethyl azodicarboxylate

(1R)-1-[2-(2-fluorophenyl)-2-oxiranyl] ethanol

→

[(1S)-1-[(2R)-2-(2-fluorophenyl)-2-oxiranyl)ethyl] 3,5-dinitrobenzoate

Lösungsmittel

water

ethyl acetate

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigesynthesized by the method
2. 2
   Sonstigewas obtained
3. 3
   Extraktionthe aqueous layer was extracted with ethyl acetate (600 ml, 400 ml)
4. 4
   Waschenwashed with water
5. 5
   Trocknena saturated aqueous solution of sodium chloride successively, then dried over anhydrous magnesium sulfate
6. 6
   Einengenconcentrated
7. 7
   SonstigeThe residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=5/1)

Vorschrift

In the same manner as in Reference Example 1, starting from 2-(2-fluorophenyl)-2-[(1R)-1-(3,4,5,6-tetrahydro-2H-pyran-2-yl)oxyethyl]oxirane (synthesized by the method described in EP 0548553A), (1R)-1-[2-(2-fluorophenyl)-2-oxiranyl] ethanol was obtained. To a solution of this product (34.77 g) in tetrahydrofuran (600 ml) were added, with ice cooling, 127.21 g of triphenyl phosphine, 102.88 g of 3,5-dinitrobenzoic acid and 84.47g of diethyl azodicarboxylate, and the resulting mixture was stirred at room temperature for 7 hours under an atmosphere of argon. To the reaction solution were added 600 ml of ethyl acetate, 100 ml of diisopropyl ether and 800 ml of water to fractionate and the aqueous layer was extracted with ethyl acetate (600 ml, 400 ml). The organic layers were combined, washed with water and a saturated aqueous solution of sodium chloride successively, then dried over anhydrous magnesium sulfate and concentrated. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=5/1) to give 23.15 g of [(1S)-1-[(2R)-2-(2-fluorophenyl)-2-oxiranyl)ethyl] 3,5-dinitrobenzoate as colorless needles.

Quelle