Reaktion #56919

Reaktionsgleichung

4-(5-bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine

2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol

2-morpholin-4-yl-ethanol

→

4-[5-bromo-2-(2-morpholin-4-yl-ethoxy)-phenyl)-6-chloro-pyrimidin-2-ylamine

Ausbeute 41.0%

Reaktionsbedingungen

Vorschrift

Following the method described in Example 135 for the synthesis of 4-(5-bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine, 2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol and 2-morpholin-4-yl-ethanol provided 4-[5-bromo-2-(2-morpholin-4-yl-ethoxy)-phenyl)-6-chloro-pyrimidin-2-ylamine (41% yield).

Quelle