Reaktion #56918

Reaktionsgleichung

4-(5-bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine

2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol

→

4-(5-bromo-2-butoxy-phenyl)-6-chloro-pyrimidin-2-ylamine

Ausbeute 51.0%

Lösungsmittel

butan-1-ol

Reaktionsbedingungen

Vorschrift

Following the method described in Example 135 for the synthesis of 4-(5-bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine, 2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol and butan-1-ol provided 4-(5-bromo-2-butoxy-phenyl)-6-chloro-pyrimidin-2-ylamine (51% yield).

Quelle