Reaktion #569141

Reaktionsgleichung

2-mercaptobenzothiophene

N-benzylpiperazine

→

title compound

Ausbeute 46.5%

1-Benzyl-4-(benzothiophen-2-yl)piperazine

Ausbeute 46.5%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture heated
2. 2
   Temperaturat reflux for 1.5 h
3. 3
   workup.WAITLeft
4. 4
   Temperaturto cool
5. 5
   Einengenconcentrated in vacuo and product
6. 6
   Sonstigerecrystallised from diethyl ether-hexane

Vorschrift

To a solution of 2-mercaptobenzothiophene (1.8 g, 10.8 mmol) in toluene under nitrogen was added N-benzylpiperazine (1.88 ml, 10.8 mmol) and the mixture heated at reflux for 1.5 h. Left to cool, concentrated in vacuo and product recrystallised from diethyl ether-hexane to yield the title compound (1.55 g), m.p. 160°-161° C.

Quelle