Reaktion #568994

Reaktionsgleichung

ammonium hydroxide

dimethylaluminum chloride

triethylamine

(1α,3β,17Z)-dimethyl[[1-[(triethylsilyl)oxy]pregna-5,7,17(20)-trien-3-yl]oxy](1,1,2-trimethylpropyl)silane

[(1,1-dimethylethyl)dimethylsilyl]oxy-4-methyl-2-pentynal

→

(1α,3β)-25-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[[dimethyl(1,1,2-trimethylpropyl)silyl]oxy]-1-[(triethylsilyl)oxy]cholesta-5,7,16-trien-23-yn-22-ol

Lösungsmittel

hexane

hexane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA 3-L three-necked flask equipped with a mechanical stirrer
2. 2
   workup.ADDITIONthermometer, addition funnel
3. 3
   workup.WAITAfter 5 min
4. 4
   Sonstigethe cold-bath was removed
5. 5
   workup.STIRRINGthe mixture was stirred for 2 hr (Gas evolved)
6. 6
   workup.ADDITIONThen, 147 g of powder Na2SO4 was added
7. 7
   workup.WAITthe stirring was continued for 30 min
8. 8
   SonstigeThe solid was removed by filtration
9. 9
   Waschenwashed with a total of 720 mL of hexane
10. 10
    WaschenThe combined hexane solutions were washed with 480 mL of 95% methanol
11. 11
    ExtraktionThe methanol layer was extracted with 240 mL of hexane
12. 12
    TrocknenThe combined hexane solutions were dried over Na2SO4
13. 13
    Einengenconcentrated
14. 14
    SonstigeThe residue was then dried under high vacuum overnight

Vorschrift

A 3-L three-necked flask equipped with a mechanical stirrer, thermometer, addition funnel, and Ar-inlet tube was charged with 91.9 g (160 mmol) of (1α,3β,17Z)-dimethyl[[1-[(triethylsilyl)oxy]pregna-5,7,17(20)-trien-3-yl]oxy](1,1,2-trimethylpropyl)silane, 62.8 mL (240 mmol) of 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy-4-methyl-2-pentynal, and 480 mL of hexane. After cooling to -75° C., 480 mL (480 mmol) of a 1M dimethylaluminum chloride solution in hexane was added over 1 hr. After stirring at -75° C. for 1.5 hr., 66.9 mL (480 mmol) of triethylamine was added followed by 147 mL of ammonium hydroxide over 5 min. After 5 min, the cold-bath was removed, and the mixture was stirred for 2 hr (Gas evolved). Then, 147 g of powder Na2SO4 was added, and the stirring was continued for 30 min. The solid was removed by filtration and washed with a total of 720 mL of hexane. The combined hexane solutions were washed with 480 mL of 95% methanol. The methanol layer was extracted with 240 mL of hexane. The combined hexane solutions were dried over Na2SO4 and concentrated. The residue was then dried under high vacuum overnight to give 153 g (overweight) of crude (1α,3β)-25-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[[dimethyl(1,1,2-trimethylpropyl)silyl]oxy]-1-[(triethylsilyl)oxy]cholesta-5,7,16-trien-23-yn-22-ol as a brown viscous oil.

Quelle