Reaktion #56889

Reaktionsgleichung

3-(4-amino-phenyl)-propionic acid

lithium aluminum hydride

→

3-(4-amino-phenyl)-propan-1-ol

Ausbeute 89.0%

Lösungsmittel

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe mixture was quenched by addition of methanol (5 ml)
2. 2
   Einengenconcentrated under reduced pressure
3. 3
   workup.ADDITIONThe residue was treated with saturated aqueous sodium chloride solution (100 ml)
4. 4
   Extraktionextracted with ethyl acetate (200 ml)
5. 5
   ExtraktionThe organic extract
6. 6
   Einengenwas concentrated under reduced pressure

Vorschrift

To a mixture of 3-(4-amino-phenyl)-propionic acid (1.85 g, 11.2 mmol) and tetrahydrofuran′(200 ml), was added lithium aluminum hydride (1.0 g, 26 mmol). After stirring for 3 hours, the mixture was quenched by addition of methanol (5 ml) and concentrated under reduced pressure. The residue was treated with saturated aqueous sodium chloride solution (100 ml) and extracted with ethyl acetate (200 ml). The organic extract was concentrated under reduced pressure to give 3-(4-amino-phenyl)-propan-1-ol (1.5 g, 89% yield).

Quelle