Reaktion #56882

ord-47733bb9bdf34592b169a13dab6e89bd

Reaktionsgleichung

Cc1ccc(Br)cc1-c1cc(Cl)nc(N)n1
4-(5-bromo-2-methyl-phenyl)-6-chloro-pyrimidin-2-ylamine
Nc1ccc([N+](=O)[O-])cc1
4-nitro-phenylamine
Cc1ccc(Br)cc1-c1cc(Nc2ccc([N+](=O)[O-])cc2)nc(N)n1
title compound
Ausbeute 74.0%
Cc1ccc(Br)cc1-c1cc(Nc2ccc([N+](=O)[O-])cc2)nc(N)n1
6-(5-Bromo-2-methyl-phenyl)-N*4*-(4-nitro-phenyl)-pyrimidine-2,4-diamine
Ausbeute 74.0%

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following the method described in Example 26, 4-(5-bromo-2-methyl-phenyl)-6-chloro-pyrimidin-2-ylamine and 4-nitro-phenylamine provided the title compound (74% yield). 1H NMR (CD3OD) δ 2.41 (s, 3H, CH3), 6.42 (s, 1H, Ar), 7.39 (d, 1H, J=8.0 Hz, Ar), 7.67-7.70 (m, 2H, Ar), 8.14 (d, 2H, J=9.0 Hz, Ar), 8.31-8.34 (m, 2H, Ar).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07419984B2uspto-grants-2008_09