Reaktion #56868

Reaktionsgleichung

title compound

6-(5-Chloro-2-methyl-phenyl)-N*4*-(4-trifluoromethyl-phenyl)-pyrimidine-2,4-diamine

succinic anhydride

→

1-[4-(5-chloro-2-methyl-phenyl)-6-(4-trifluoromethyl-phenylamino)-pyrimidin-2-yl]-pyrrolidine-2,5-dione

Ausbeute 96.0%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturunder reflux for 6 hours
3. 3
   Filtrationthe mixture was filtered
4. 4
   WaschenThe filtrate was washed with saturated aqueous sodium bicarbonate solution (3×10 ml)
5. 5
   Trocknendried over magnesium sulfate
6. 6
   Einengenconcentrated under reduced pressure

Vorschrift

A mixture of the title compound of Example 29 (0.19 g, 0.50 mmol) and succinic anhydride (0.30 g, 3.0 mmol) in toluene (18 ml) was heated under reflux for 6 hours. After cooled to room temperature, the mixture was filtered. The filtrate was washed with saturated aqueous sodium bicarbonate solution (3×10 ml), dried over magnesium sulfate, and concentrated under reduced pressure to provide 1-[4-(5-chloro-2-methyl-phenyl)-6-(4-trifluoromethyl-phenylamino)-pyrimidin-2-yl]-pyrrolidine-2,5-dione as a white solid (96% yield).

Quelle