Reaktion #568665

Reaktionsgleichung

4-chloro 6-methyl quinazolone

m-trifluoromethylaniline

→

8-methyl 4 chloro quinazoline

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionTreatment with aqueous Na2CO3 and extraction with CH2Cl2
2. 2
   Sonstigegave 0.2 g of P15 as a white solid, mp-215° C.

Vorschrift

0.45 g of 4-chloro 6-methyl quinazolone and 0.405 g, of m-trifluoromethylaniline in 20 ml ethanol were refluxed 1 hour. Treatment with aqueous Na2CO3 and extraction with CH2Cl2 gave 0.2 g of P15 as a white solid, mp-215° C., as the free base. NMR CDCl3 δ 8.78 (1H,S), 8.06 (2H,m), 7.86(1H,d,J=7.6 Hz), 7.65 (2H,m), 7.54(1H,t,J=8.0 Hz), 7.42 (1H,m), 2.58 (3H,S).

Quelle