Reaktion #568446

Reaktionsgleichung

1-bromodecan-10-ol

3,4-dihydro-2H-pyran

→

1-bromo-10-[tetrahydropyranyloxy]decane

Ausbeute 42.8%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe reaction mixture evaporated down
2. 2
   SonstigeThe residue is purified by column chromatography on silica gel

Vorschrift

A mixture of 100 g 1-bromodecan-10-ol, 2.1 g bis(trimethylsilyl)sulphate, 43 g 3,4-dihydro-2H-pyran and 500 ml dichloromethane is stirred for 6 hours at room temperature. Several drops of pyridine are added and the reaction mixture evaporated down. The residue is purified by column chromatography on silica gel using hexane/ethyl acetate (1/1 v/v) as eluent to yield 58 g of 1-bromo-10-[tetrahydropyranyloxy]decane.

Quelle