Reaktion #56805

Reaktionsgleichung

4,6-dichloro-pyrimidin-2-yl-amine

p-tolylamine

N,N-diisopropylethylamine

→

6-chloro-N*4*-p-tolyl-pyrimidine-2,4-diamine

Ausbeute 60.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturunder reflux for 40 hours
3. 3
   Filtrationfiltration

Vorschrift

A mixture of 4,6-dichloro-pyrimidin-2-yl-amine (3.3 g, 20 mmol), p-tolylamine (3.4 g, 32 mmol) and N,N-diisopropylethylamine (12 ml) in ethanol (150 ml) was heated under reflux for 40 hours. After cooling to room temperature, filtration provided 6-chloro-N*4*-p-tolyl-pyrimidine-2,4-diamine (2.8 g, 60% yield) as a white solid.

Quelle