Reaktion #566985

Reaktionsgleichung

N-Boc-nipecotic acid

aniline

DCC

→

1-Boc-piperidine-3-carboxylic acid phenyl amide

Ausbeute 89.0%

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationFiltration and removal of the solvent
2. 2
   Sonstigegave oily crude product, which
3. 3
   Sonstigewas purified by flash column chromatography (silica gel, hexane:ethyl acetate)

Vorschrift

To a solution of N-Boc-nipecotic acid 33 (102 mg, 0.445 mmol) and aniline (41 μL, 1.0 eq.) in 2 mL of dry CH2Cl2 was added DCC-resin (430 mg). The reaction mixture was shaken at room temperature overnight. Filtration and removal of the solvent gave oily crude product, which was purified by flash column chromatography (silica gel, hexane:ethyl acetate) to afford 1-Boc-piperidine-3-carboxylic acid phenyl amide 34 as a colorless oil (120 mg, 89%).

Quelle