Reaktion #56680

Reaktionsgleichung

Isopropyl ether

pyridine

phosphorus pentachloride

Benzhydryl 7β-phenylacetylamino-3-[4-(4-pyridyl)-2-thiazolylthio]-3-cephem-4-carboxylate

→

benzhydryl 7β-amino-3-[4-(4-pyridyl)-2-thiazolylthio]-3-cephem-4-carboxylate

Lösungsmittel

Isobutanol

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooling
2. 2
   Temperaturcooling for 1 hr
3. 3
   workup.STIRRINGthe mixture was stirred at room temperature for 1 hr
4. 4
   workup.STIRRINGthe mixture was stirred for 10 min
5. 5
   SonstigeThe solvent was removed by decantation
6. 6
   workup.ADDITIONsaturated aqueous sodium hydrogencarbonate solution (200 mL) was added dropwise
7. 7
   workup.STIRRINGafter which the mixture was stirred for 15 min
8. 8
   Trocknendried over magnesium sulfate
9. 9
   Filtrationfiltrated
10. 10
    SonstigeThe solvent was evaporated off under reduced pressure
11. 11
    workup.ADDITIONIsopropyl ether (60 mL) was added to the residue
12. 12
    Filtrationthe precipitated powder was collected by filtration
13. 13
    Waschenwashed with isopropyl ether (20 mL)
14. 14
    Sonstigedried under reduced pressure

Vorschrift

Benzhydryl 7β-phenylacetylamino-3-[4-(4-pyridyl)-2-thiazolylthio]-3-cephem-4-carboxylate (4.15 g, 6.0 mmol) was dissolved in dichloromethane (60 mL) and pyridine (0.726 mL, 9.0 mmol) and phosphorus pentachloride (1.87 g, 9.0 mmol) were successively added under ice-cooling. The mixture was stirred under ice-cooling for 1 hr. Isobutanol (8.0 mL) was added at once to the reaction mixture, and the mixture was stirred at room temperature for 1 hr. Isopropyl ether (300 mL) was added dropwise and the mixture was stirred for 10 min. The solvent was removed by decantation. The residual oil was suspended in ethyl acetate (600 mL) and saturated aqueous sodium hydrogencarbonate solution (200 mL) was added dropwise, after which the mixture was stirred for 15 min. The organic layer was separately taken, dried over magnesium sulfate and filtrated. The solvent was evaporated off under reduced pressure. Isopropyl ether (60 mL) was added to the residue, and the precipitated powder was collected by filtration, washed with isopropyl ether (20 mL) and dried under reduced pressure. yield: 3.18 g (95%)

Quelle