Reaktion #566183

Reaktionsgleichung

toluene

2-(4-chlorophenyl)-2-(3,4,5,6-tetrahydro-[2H]-pyran-2-yloxy)ethyl methanesulfonate

p-toluenesulfonic acid monohydrate

→

(R)-2-(4-chlorophenyl)-2-hydroxyethyl Methanesulfonate

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe reaction mixture was washed with a saturated aqueous sodium hydrogen carbonate solution
2. 2
   Trocknenwith a saturated aqueous sodium chloride solution, and dried with anhydrous magnesium sulfate
3. 3
   FiltrationThe desiccant was filtered off
4. 4
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
5. 5
   Sonstigeto obtain a colorless oily compound

Vorschrift

Into toluene (10 ml) were added 2-(4-chlorophenyl)-2-(3,4,5,6-tetrahydro-[2H]-pyran-2-yloxy)ethyl methanesulfonate (3.0 g), p-toluenesulfonic acid monohydrate (1.7 g) and methanol (0.5 g), and the resulting mixture was stirred at 50° C. for 1 hour. The reaction mixture was washed with a saturated aqueous sodium hydrogen carbonate solution, then with a saturated aqueous sodium chloride solution, and dried with anhydrous magnesium sulfate. The desiccant was filtered off and then the solvent was distilled off under reduced pressure to obtain a colorless oily compound mentioned above (2.0 g, 89.0%).

Quelle