Reaktion #565997

ord-e4f3e625f0e14d7ba486f2a7638064a4

Reaktionsgleichung

C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)O
3-chlorophenylacetyl alanine
C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)O
N-(3-chlorophenylacetyl)alanine
C=C(C)CO
2-methylprop-2-en-1-ol
→
C=C(C)COC(=O)[C@H](C)NC(=O)Cc1cccc(Cl)c1
title compound
C=C(C)COC(=O)[C@H](C)NC(=O)Cc1cccc(Cl)c1
N-[(3-chlorophenyl)acetyl]alanine 2-methylprop-2-enyl Ester

Edukte

C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)O
3-chlorophenylacetyl alanine
C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)O
N-(3-chlorophenylacetyl)alanine
C=C(C)CO
2-methylprop-2-en-1-ol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following General Procedure C above, and using N-(3-chlorophenylacetyl alanine (from Example D above) and 2-methylprop-2-en-1-ol (Aldrich) the title compound can be prepared. The reaction was monitored by tlc on silica gel and purification was by liquid chromatography using 3:7 EtOAc:hexane as the eluant.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06642261B2uspto-grants-2003_11