Reaktion #565994

ord-14b0b2b745cf44b5a0df36d09dae0af5

Reaktionsgleichung

C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)O
alanine
C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)O
N-(3-chlorophenylacetyl)alanine
CC1(CO)CC1
(1-methylcyclopropyl)methanol
→
C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)OCC1(C)CC1
title compound
C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)OCC1(C)CC1
N-[(3-chlorophenyl)acetyl]alanine (1-methylcyclopropyl)methyl ester

Edukte

C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)O
alanine
C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)O
N-(3-chlorophenylacetyl)alanine
CC1(CO)CC1
(1-methylcyclopropyl)methanol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following General Procedure C above, and using N-(3-chloroph,enylacetyl alanine (from Example D above) and (1-methylcyclopropyl)methanol (Aldrich) the title compound can be prepared. The reaction was monitored by tlc on silica gel and purification was by liquid chromatography using 3:7 EtOAc:hexane as the eluant. NMR data was as follows:

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06642261B2uspto-grants-2003_11