Reaktion #565993

ord-c6804ae147164d37802f8c72a02ead6e

Reaktionsgleichung

C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)O
3chlorophenylacetyl alanine
C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)O
N-(3-chlorophenylacetyl)alanine
OCc1cccs1
2-thiophenemethanol
→
C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)OCc1cccs1
title compound
C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)OCc1cccs1
N-[(3chlorophenyl)acetyl]alanine 2-thienylmethyl ester

Edukte

C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)O
3chlorophenylacetyl alanine
C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)O
N-(3-chlorophenylacetyl)alanine
OCc1cccs1
2-thiophenemethanol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following General Procedure C above, and using N-(3chlorophenylacetyl alanine (from Example D above) and 2-thiophenemethanol (Aldrich) the title compound can be prepared. The reaction was monitored by tlc on silica gel and purification was by liquid chromatography using 3:7 EtOAc:hexane as the eluant.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06642261B2uspto-grants-2003_11