Reaktion #56590

Reaktionsgleichung

2-(6-chlorohexyloxy)tetrahydropyrane

hydroquinone

potassiumcarbonate

potassiumiodide

→

product

Ausbeute 82.5%

4-(6-(2-Tetrahydropyranyl)oxyhexyloxy)phenol

Ausbeute 82.5%

Lösungsmittel

dimethylsulfoxide

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto react for 4 days at 80° C
2. 2
   Extraktionextracted with ether
3. 3
   TrocknenThe organic phase was then dried over sodium sulphate
4. 4
   Filtrationfiltered
5. 5
   Einengenconcentrated to dryness

Vorschrift

A mixture of 10 g of 2-(6-chlorohexyloxy)tetrahydropyrane, 25 g of hydroquinone, 31 g of potassiumcarbonate, 0.752 g of potassiumiodide and 250 ml of dimethylsulfoxide was allowed to react for 4 days at 80° C. Subsequently, the reaction mixture was cooled to room temperature and after addition of water extracted with ether. The organic phase was then dried over sodium sulphate, filtered and concentrated to dryness. Chromatography on silica with 10% ethylacetate in toluene gave 11 g of product as a yellowish oil.

Quelle