Reaktion #56583

Reaktionsgleichung

z,z,z-Octadeca-6,9,12-trienoyl chloride

1,5-dihydroxypentane

triethylamine

→

1-(z,z,z-octadeca-6,9,12-trienoyloxy)-5-hydroxypentane

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeOn completion of reaction
2. 2
   Waschenwas washed with dilute hydrochloric acid and water
3. 3
   Sonstigedried
4. 4
   Sonstigepurified by column chromatography

Vorschrift

z,z,z-Octadeca-6,9,12-trienoyl chloride (2 g) was added dropwise to a solution of 1,5-dihydroxypentane (3.5 g), triethylamine (0.94 ml) and 4-(N,N-dimethylamino)pyridine (0.2 g) in methylene chloride (50 ml) with stirring at 0° C. under nitrogen. On completion of reaction as evidenced by tic the reaction mixture was washed with dilute hydrochloric acid and water, dried and purified by column chromatography yielding 1-(z,z,z-octadeca-6,9,12-trienoyloxy)-5-hydroxypentane as a pale yellow oil.

Quelle