Reaktion #565302

ord-85d3b19408e043de9bece49c216dc886

Reaktionsgleichung

N[C@@H](CCC(=O)O)C(=O)OCc1ccccc1
L-glutamic acid-mono-benzyl ester
CCOC(=O)C(F)(F)F
trifluoroacetic acid ethyl ester
→
O=C(O)CC[C@H](NC(=O)C(F)(F)F)C(=O)OCc1ccccc1
N-Trifluoroacetyl-L-glutamic acid-mono-benzyl ester

Edukte

N[C@@H](CCC(=O)O)C(=O)OCc1ccccc1
L-glutamic acid-mono-benzyl ester
CCOC(=O)C(F)(F)F
trifluoroacetic acid ethyl ester

Reagenzien

Keine

Lösungsmittel

CCO
ethanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeIt is evaporated to the dry state
  2. 2
    Sonstigethe residue is crystallized from diisopropyl ether

Vorschrift

100 g (421.5 mmol) of L-glutamic acid-mono-benzyl ester is dissolved in a mixture that consists of 1000 ml of trifluoroacetic acid ethyl ester/500 ml of ethanol, and it is stirred for 24 hours at room temperature. It is evaporated to the dry state, and the residue is crystallized from diisopropyl ether.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06641797B2uspto-grants-2003_11