Reaktion #565288

Reaktionsgleichung

12-cyclohexyldodecanol

epichlorohydrin

sodium hydroxide

→

1,2-epoxy-3-(12-cyclohexyldodecyloxy)propane

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe reaction mixture was washed with water
2. 2
   Trocknendried (anhydrous magnesium sulfate)
3. 3
   Einengenconcentrated under reduced pressure
4. 4
   Wascheneluted with hexane-ethyl acetate (30:1)

Vorschrift

A mixture of 26.5 g (99 millimole) of 12-cyclohexyldodecanol, 27.4 g (296 millimole) of epichlorohydrin, 52.6 g (658 millimole) of 50% aqueous solution of sodium hydroxide, 2.0 g of cetyltrimethylammonium chloride and 300 ml of toluene was stirred at 60° C. for 24 hours. The reaction mixture was washed with water, dried (anhydrous magnesium sulfate), and concentrated under reduced pressure. The residue was subjected to silica gel (550 g) column chromatography, and eluted with hexane-ethyl acetate (30:1), to give 1,2-epoxy-3-(12-cyclohexyldodecyloxy)propane as colorless oil.

Quelle