Reaktion #56527

Reaktionsgleichung

2-chloro-5-nitro-benzotrifluoride

sodium hydroxide

methanol

water

→

2-methoxy-5-nitro-benzotrifluoride

Ausbeute 60.7%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with methylene chloride
2. 2
   SonstigeAfter evaporating off the solvent
3. 3
   Sonstigethe compound is recrystallised from isopropanol

Vorschrift

45 g of sodium hydroxide and 10 g of tetraethylammonium chloride in 200 g of methanol are initially introduced, 112.5 g of 2-chloro-5-nitro-benzotrifluoride are added dropwise at 25° to 30° C. and the mixture is then stirred at 30° C. for a further 5 hours. The mixture is then poured into 250 ml of water and extracted with methylene chloride. After evaporating off the solvent, the compound is recrystallised from isopropanol. 67 g of 2-methoxy-5-nitro-benzotrifluoride with a melting point of 70° to 74° C. are obtained.

Quelle