Reaktion #56525

Reaktionsgleichung

hydrochloric acid

2-chloro-3-nitro-5-trifluoromethyl-benzoic acid

methanol

sodium hydroxide

→

2-hydroxy-3-nitro-5-trifluoromethylbenzoic acid

Lösungsmittel

H2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONare added dropwise
2. 2
   workup.STIRRINGThe mixture is subsequently stirred at 65° C. for 5 hours
3. 3
   FiltrationThe solid product is filtered off
4. 4
   Sonstigerecrystallised from water

Vorschrift

27 g of 2-chloro-3-nitro-5-trifluoromethyl-benzoic acid and 1 g of tetraethylammonium chloride are initially introduced into 200 ml of methanol, and 70 g of 50% strength sodium hydroxide solution are added dropwise, whilst stirring. The mixture is subsequently stirred at 65° C. for 5 hours, diluted with 300 ml of H2O and then rendered acid with hydrochloric acid. The solid product is filtered off and recrystallised from water. 16 g of 2-hydroxy-3-nitro-5-trifluoromethylbenzoic acid with the melting point: 166° to 168° C. are obtained.

Quelle