Reaktion #56522

Reaktionsgleichung

sodium hydroxide

hydrochloric acid

4-(2',4'-Difluorophenyl)phenylacetate

→

4-(2,4-difluorophenyl)phenol

Lösungsmittel

water

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthermometer and reflux condenser
2. 2
   workup.ADDITIONcharged with 2.62 kg
3. 3
   Temperaturthe batch is heated
4. 4
   Temperaturto reflux over 2.5 hours
5. 5
   TemperaturThe batch is refluxed for 2 hours (in solution at 75°)
6. 6
   Temperaturcooled to 100°

Vorschrift

A 30 liter resin pot is fitted with stirrer, thermometer and reflux condenser, and charged with 2.62 kg. of 50% aqueous sodium hydroxide and 11.34 liters of water. 4-(2',4'-Difluorophenyl)phenylacetate (1.876 kg., 7.55 m) is added and the batch is heated to reflux over 2.5 hours. The batch is refluxed for 2 hours (in solution at 75°), then cooled to 100° and added to a solution of 3.27 liters of concentrated hydrochloric acid in 9.8 liters of water in a 50 liter resin pot over a 30 minute period.

Quelle