Reaktion #565180

Reaktionsgleichung

hydrazoic acid

5-(p-carboxyphenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

sulfuric acid

→

title compound

5-(p-Aminophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]-pyridine

Lösungsmittel

ethylene dichloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture is heated to 40°
2. 2
   Sonstigethe reaction mixture is evaporated
3. 3
   workup.DISSOLUTIONThe residue is redissolved in water
4. 4
   ExtraktionThe aqueous phase is extracted with methylene chloride (3×30 ml)
5. 5
   TrocknenThe organic extracts are dried over potassium carbonate
6. 6
   Sonstigeevaporated

Vorschrift

A solution of 2.42 g of 5-(p-carboxyphenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine in 100 ml of ethylene dichloride is treated with 6 ml of concentrated sulfuric acid. The reaction mixture is heated to 40° and 6 ml of hydrazoic acid (2M in ethylene dichloride) is added dropwise. When gas evolution has ceased, the reaction mixture is evaporated. The residue is redissolved in water and adjusted to pH 10. The aqueous phase is extracted with methylene chloride (3×30 ml). The organic extracts are dried over potassium carbonate and evaporated to yield the title compound.

Quelle