Reaktion #56518

Reaktionsgleichung

9-hydroxy-1-oxo-1H-naphtho[2,1-b]pyran-2-carboxaldehyde acetate

hydroxylamine hydrochloride

sodium formate

→

9-Hydroxy-1-oxo-1H-naphtho[2,1-b]pyran-2-carbonitrile

Lösungsmittel

formic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis refluxed for 30 hrs
2. 2
   SonstigeThe product crystallize
3. 3
   Temperaturon cooling
4. 4
   Filtrationis filtered
5. 5
   Waschenwashed with acetone

Vorschrift

A mixture of 9-hydroxy-1-oxo-1H-naphtho[2,1-b]pyran-2-carboxaldehyde acetate (1 mm), hydroxylamine hydrochloride (1.3 mm) and sodium formate (2 mm) is refluxed for 30 hrs. in formic acid (3 parts). The product crystallize on cooling, is filtered and washed with acetone. The dry crystals are light beige, m.p. 289°-92° C.

Quelle