Reaktion #565171

Reaktionsgleichung

5-(p-formylphenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

hydrazoic acid

sulfuric acid

→

title compound

5-(p-Cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]-pyridine

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONis added dropwise
2. 2
   SonstigeThe organic phase is separated
3. 3
   Trocknendried over sodium sulfate
4. 4
   Sonstigeevaporated
5. 5
   Sonstigeto yield an oil which
6. 6
   Sonstigeis chromatographed on silica gel with ethyl acetate

Vorschrift

A solution of 2.01 g of 5-(p-formylphenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine and 0.96 g of hydrazoic acid in 30 ml benzene is maintained by external cooling at room temperature, while 0.8 ml of concentrated sulfuric acid is added dropwise. The reaction mixture is stirred for 2 h and neutralized. The organic phase is separated, dried over sodium sulfate and evaporated to yield an oil which is chromatographed on silica gel with ethyl acetate to yield the title compound.

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