Reaktion #56514

ord-6eb2b93ab2e043f581feb58860e38c20

Reaktionsgleichung

CC(=O)O.O=Cc1coc2ccc3ccc(O)cc3c2c1=O
Compound 5
CC(=O)O.O=Cc1coc2ccc3ccc(O)cc3c2c1=O
9-hydroxy-1-oxo-1-H-naphtho[2,1-b]pyran-2-carboxaldehyde acetate
O=C(O)CC(=O)O
malonic acid
→
C=C(C(=O)O)c1coc2ccc3ccc(OC(C)=O)cc3c2c1=O
[9-(acetyloxy)-1-oxo-1H-naphtho[2,1-b]pyran-2-yl]-2-propenoic acid

Edukte

CC(=O)O.O=Cc1coc2ccc3ccc(O)cc3c2c1=O
Compound 5
CC(=O)O.O=Cc1coc2ccc3ccc(O)cc3c2c1=O
9-hydroxy-1-oxo-1-H-naphtho[2,1-b]pyran-2-carboxaldehyde acetate
O=C(O)CC(=O)O
malonic acid

Reagenzien

Keine

Lösungsmittel

c1ccncc1
pyridine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Thus, Compound 5 is refluxed with malonic acid in pyridine to obtain [9-(acetyloxy)-1-oxo-1H-naphtho[2,1-b]pyran-2-yl]-2-propenoic acid, compound 7. Additionally, Compound 6 may be refluxed in a similar fashion with malonic acid in pyridine to obtain [9-hydroxy-1-oxo-1H-naphtho[2,1-b]pyran-2-yl]-2-propenoic acid, Compound 7A.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04225722uspto-grants-1980_09