Reaktion #564697

ord-a321c664fc98473db367a08e9d70eb1d

Reaktionsgleichung

[Na+].[OH-]
sodium hydroxide
CCCc1c(OCCCOc2ccc3c(c2CCC)OC(C)(CCC(=O)N2CCC[C@H]2C(=O)OC)CC3=O)ccc(C(C)=O)c1O
title product
CCCc1c(OCCCOc2ccc3c(c2CCC)OC(C)(CCC(=O)N2CCC[C@H]2C(=O)OC)CC3=O)ccc(C(C)=O)c1O
N-(3-[7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]-3,4-dihydro-2-methyl-4-oxo-8-propyl-2H-1-benzopyran-2-yl]propanoyl}-L-proline methyl ester
→
CCCc1c(OCCCOc2ccc3c(c2CCC)OC(C)(CCC(=O)N2CCC[C@H]2C(=O)O)CC3=O)ccc(C(C)=O)c1O
title compound
CCCc1c(OCCCOc2ccc3c(c2CCC)OC(C)(CCC(=O)N2CCC[C@H]2C(=O)O)CC3=O)ccc(C(C)=O)c1O
N-{3-[7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]-3,4-dihyro-2-methyl-4-oxo-8-propyl-2H-1-benzopyran-2-yl]propanoyl}-L-proline

Edukte

[Na+].[OH-]
sodium hydroxide
CCCc1c(OCCCOc2ccc3c(c2CCC)OC(C)(CCC(=O)N2CCC[C@H]2C(=O)OC)CC3=O)ccc(C(C)=O)c1O
title product
CCCc1c(OCCCOc2ccc3c(c2CCC)OC(C)(CCC(=O)N2CCC[C@H]2C(=O)OC)CC3=O)ccc(C(C)=O)c1O
N-(3-[7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]-3,4-dihydro-2-methyl-4-oxo-8-propyl-2H-1-benzopyran-2-yl]propanoyl}-L-proline methyl ester

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared by the method of Example 7 using the title product of Example 63, except that sodium hydroxide was used instead of lithium hydroxide. Structure assignment was supported by elemental analysis.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04888356uspto-grants-1989_12