Reaktion #564464

Reaktionsgleichung

4-bromo-3-methylbutanol

dihydropyran

→

2-[4-bromo-3-methylbutoxy]-tetrahydro-2H-pyran

Ausbeute 64.5%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONAfter the addition
2. 2
   workup.DISTILLATIONthe solvent was distilled off
3. 3
   SonstigeThe residue was purified by silica gel column chromatography

Vorschrift

16.7 g of 4-bromo-3-methylbutanol was dissolved in 200 ml of anhydrous methylene chloride, and with ice cooling, 10.0 g of dihydropyran was added dropwise. After the addition, the mixture was stirred at room temperature for 2 hours, and then the solvent was distilled off. The residue was purified by silica gel column chromatography using hexane/ethyl acetate as an eluent to give 16.2 g of 2-[4-bromo-3-methylbutoxy]-tetrahydro-2H-pyran. The NMR spectrum of this product was as follows:

Quelle