Reaktion #56443

Reaktionsgleichung

potassium carbonate

p-chlorobenzylmercaptan

methyl chloroacetate

potassium iodide

→

methyl p-chlorobenzylmercapto-acetate

Ausbeute 100.0%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture thus obtained
2. 2
   Temperaturheated
3. 3
   Temperaturunder reflux for 7 hours
4. 4
   TemperaturIt is cooled
5. 5
   Filtrationthe precipitate (K2CO3) is filtered off
6. 6
   Sonstigethe acetone is evaporated from the filtrate
7. 7
   WaschenThe ether solution is washed with 4 N NaOH
8. 8
   TrocknenThe ether solution is then dried over MgSO4
9. 9
   Sonstigethe ether is evaporated

Vorschrift

Anhydrous acetone (100 ml), potassium carbonate (21 g), p-chlorobenzylmercaptan (19.5 ml), methyl chloroacetate (13.2 ml) and potassium iodide (0.1 g) are mixed in the cold. The mixture thus obtained is stirred and heated under reflux for 7 hours. It is cooled, the precipitate (K2CO3) is filtered off, the acetone is evaporated from the filtrate and the residue is taken up with ether. The ether solution is washed with 4 N NaOH and then with water until the wash waters have a neutral pH. The ether solution is then dried over MgSO4, the ether is evaporated and 34.5 g (100% yield) of methyl p-chlorobenzylmercapto-acetate are collected in the form of a chromatographically pure oil.

Quelle