Reaktion #564322

Reaktionsgleichung

N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethylthiazol-4-yl) ethanamine

ethyl bromoacetate

potassium carbonate

→

N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-N-(carboethoxymethyl)-2-hydroxy-2-(2-trifluoromethylthiazol-4-yl)ethanamine

Lösungsmittel

butan-2-one

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe inorganic products are removed by filtration
2. 2
   Sonstigethe solvent is removed by distillation
3. 3
   SonstigeThe remaining oil is purified on a silica gel column
4. 4
   SonstigeA colourless oil is obtained

Vorschrift

0.21 g (0.005 mol) of N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethylthiazol-4-yl) ethanamine is dissolved in 10 ml of butan-2-one, and 0.5 ml of ethyl bromoacetate and 0.5 g of potassium carbonate are added, and the mixture is stirred at room temperature for 16 hours. The inorganic products are removed by filtration, and the solvent is removed by distillation. The remaining oil is purified on a silica gel column using toluene/ethyl acetate=85:15 as eluant. A colourless oil is obtained.

Quelle