Reaktion #564297

Reaktionsgleichung

N-[2-(4-carbomethoxymethoxyphenyl)-1-methylethyl]-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine

sodium hydroxide

→

N-[2-(4-Carboxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionAfter neutralisation with 1N hydrochloric acid, the mixture is extracted
2. 2
   Sonstigethe extract is evaporated to dryness
3. 3
   Sonstigethe remaining residue is triturated with petroleum ether
4. 4
   Filtrationfiltered off with suction

Vorschrift

Prepared analogously to Example 16 by reaction of N-[2-(4-carbomethoxymethoxyphenyl)-1-methylethyl]-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine in methanol with 1N sodium hydroxide solution. After neutralisation with 1N hydrochloric acid, the mixture is extracted by shaking with methylene chloride, the extract is evaporated to dryness, and the remaining residue is triturated with petroleum ether and filtered off with suction.

Quelle