Reaktion #564285

Reaktionsgleichung

2-(4-carbomethoxymethoxyphenyl)-1-methyl-ethanamine

2-trifluoromethyl-4-bromoacetyl-thiazole

→

N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefollowed by reduction and purification of the base on a silica gel column with methylene chloride/methanol=20:1 as eluant

Vorschrift

Prepared analogously to Example 3 by reaction of 2-(4-carbomethoxymethoxyphenyl)-1-methyl-ethanamine with 2-trifluoromethyl-4-bromoacetyl-thiazole followed by reduction and purification of the base on a silica gel column with methylene chloride/methanol=20:1 as eluant.

Quelle