Reaktion #564284

ord-f8599ee95de740f29d6d531182f46c3a

Reaktionsgleichung

COC(=O)c1ccc(CC(C)NCC(O)c2csc(C(F)(F)F)n2)cc1
N-[2-(4-carbomethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine
COC(=O)C=O
methyl glyoxylate
→
COC(=O)c1ccc(CC(C)N2CC(c3csc(C(F)(F)F)n3)OC2C(=O)OC)cc1
Methyl 3-[2-(4-carbomethoxyphenyl)-1-methylethyl]-5-(2-trifluoromethyl-thiazol-4-yl)-2-oxazolidine carboxylate

Edukte

COC(=O)c1ccc(CC(C)NCC(O)c2csc(C(F)(F)F)n2)cc1
N-[2-(4-carbomethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine
COC(=O)C=O
methyl glyoxylate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared analogously to Example 18 by reaction of N-[2-(4-carbomethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine with methyl glyoxylate.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04886814uspto-grants-1989_12