Reaktion #56423

Reaktionsgleichung

hydrogen

thiophene

ethanol

N-(4-piperidinyl)-2-pyrimidinamine

→

N-[1-(1-methylethyl)-4-piperidinyl]-2-pyrimidinamine

Lösungsmittel

methanol

2-propanone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe catalyst is filtered off
2. 2
   Sonstigethe filtrate is evaporated
3. 3
   workup.DISSOLUTIONThe residue is dissolved in trichloromethane
4. 4
   WaschenThe solution is washed successively with a diluted sodium hydroxide solution and with water
5. 5
   Sonstigedried
6. 6
   Filtrationfiltered
7. 7
   Sonstigeevaporated

Vorschrift

To 0.5 parts of a solution of 2 parts of thiophene in 40 parts of ethanol, are added 4 parts of 2-propanone, 4.5 parts of N-(4-piperidinyl)-2-pyrimidinamine and 120 parts of methanol. The whole is hydrogenated at normal pressure and at room temperature with 2 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen is taken up, the catalyst is filtered off and the filtrate is evaporated. The residue is dissolved in trichloromethane. The solution is washed successively with a diluted sodium hydroxide solution and with water, dried, filtered and evaporated, yielding 3 parts of N-[1-(1-methylethyl)-4-piperidinyl]-2-pyrimidinamine as a residue.

Quelle