Reaktion #564052

Reaktionsgleichung

p-Nitrobenzaldehyde

4-methyl-pyrimidine

acetic anhydride

→

4-[2-(p-nitrophenyl) ethenyl]pyrimidine

Ausbeute 77.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe starting compound is prepared
2. 2
   TemperaturAfter cooling
3. 3
   Extraktionthe aqueous mixture is extracted several times with chloroform
4. 4
   TrocknenThe combined chloroform extracts are dried over magnesium sulfate
5. 5
   Einengenconcentrated until crystals
6. 6
   Sonstigeseparated
7. 7
   workup.ADDITIONAddition of ether

Vorschrift

The starting compound is prepared as follows. p-Nitrobenzaldehyde (24.2 g), 4-methyl-pyrimidine (15.5 g) and acetic anhydride (16.7 g) are mixed at room temperature, and the mixture is heated at 120° C. for 5 hours. After cooling, the mixture is poured into water (500 ml), and the aqueous mixture is extracted several times with chloroform. The combined chloroform extracts are dried over magnesium sulfate and concentrated until crystals separated. Addition of ether gives 4-[2-(p-nitrophenyl) ethenyl]pyrimidine (28 g), m.p. 213°-215° C.

Quelle