Reaktion #56405

Reaktionsgleichung

4-methylbenzenesulfonic acid

ethyl 4-oxo-1-piperidinecarboxylate

4-chlorobenzenamine

methylbenzene

→

ethyl 4-[(4-chlorophenyl)imino]-1-piperidinecarboxylate

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxed for 7 hours
2. 2
   Sonstige(The reaction vessel is provided with
3. 3
   Temperatura reflux-condensor
4. 4
   SonstigeThe methylbenzene is evaporated
5. 5
   workup.DISTILLATIONthe oily residue is distilled in vacuo

Vorschrift

A mixture of 171.2 parts of ethyl 4-oxo-1-piperidinecarboxylate, 159.5 parts of 4-chlorobenzenamine, 1520 parts of anhydrous methylbenzene and a few crystals of 4-methylbenzenesulfonic acid is stirred and refluxed for 7 hours. (The reaction vessel is provided with a reflux-condensor and water-separator). The methylbenzene is evaporated and the oily residue is distilled in vacuo, yielding 192 parts of oily ethyl 4-[(4-chlorophenyl)imino]-1-piperidinecarboxylate; bp. 171°-176° C. at 0.4 mm. pressure.

Quelle